Apathy in Essential Tremor, Dystonia, and Parkinson's Disease: A Comparison with Normal Controls
Identifieur interne : 001210 ( Main/Exploration ); précédent : 001209; suivant : 001211Apathy in Essential Tremor, Dystonia, and Parkinson's Disease: A Comparison with Normal Controls
Auteurs : Elan D. Louis [États-Unis] ; Edward D. Huey [États-Unis] ; Marina Gerbin [États-Unis] ; Amanda S. Viner [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Apathy, defined as decreased goal-directed activity, has been observed in Parkinson's disease. A number of cognitive/psychiatric features have been documented in essential tremor, yet we are unaware of studies of apathy. Methods: Using the Apathy Evaluation Scale (range = 18-72 [more apathy]), we compared 79 essential tremor cases, 20 dystonia cases, and 39 Parkinson's disease cases with 80 normal controls. Results: The score of the Apathy Evaluation Scale was higher in essential tremor, dystonia, and Parkinson's disease cases than controls (all P≤.04). Parkinson's disease cases had the highest scores. Analyses stratified by presence/absence of depressive symptoms indicated the presence of a group of apathetic but nondepressed cases. Conclusions: Patients with Parkinson's disease, essential tremor, and dystonia had elevated apathy scores. Features of apathy seemed to occur in these conditions independent of depressive symptoms. The mechanistic basis for the apparent increased features of apathy in essential tremor and dystonia deserves further study.
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Louis</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Epidemiology, Mailman School of Public Health, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Huey, Edward D" sort="Huey, Edward D" uniqKey="Huey E" first="Edward D." last="Huey">Edward D. Huey</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Psychiatry, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Gerbin, Marina" sort="Gerbin, Marina" uniqKey="Gerbin M" first="Marina" last="Gerbin">Marina Gerbin</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Viner, Amanda S" sort="Viner, Amanda S" uniqKey="Viner A" first="Amanda S." last="Viner">Amanda S. Viner</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apathy</term><term>Comparative study</term><term>Depression</term><term>Dystonia</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Tremor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tremblement</term><term>Dystonie</term><term>Maladie de Parkinson</term><term>Etat dépressif</term><term>Pathologie du système nerveux</term><term>Etude comparative</term><term>Apathie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Apathy, defined as decreased goal-directed activity, has been observed in Parkinson's disease. A number of cognitive/psychiatric features have been documented in essential tremor, yet we are unaware of studies of apathy. Methods: Using the Apathy Evaluation Scale (range = 18-72 [more apathy]), we compared 79 essential tremor cases, 20 dystonia cases, and 39 Parkinson's disease cases with 80 normal controls. Results: The score of the Apathy Evaluation Scale was higher in essential tremor, dystonia, and Parkinson's disease cases than controls (all P≤.04). Parkinson's disease cases had the highest scores. Analyses stratified by presence/absence of depressive symptoms indicated the presence of a group of apathetic but nondepressed cases. Conclusions: Patients with Parkinson's disease, essential tremor, and dystonia had elevated apathy scores. Features of apathy seemed to occur in these conditions independent of depressive symptoms. The mechanistic basis for the apparent increased features of apathy in essential tremor and dystonia deserves further study.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name></region><name sortKey="Gerbin, Marina" sort="Gerbin, Marina" uniqKey="Gerbin M" first="Marina" last="Gerbin">Marina Gerbin</name><name sortKey="Huey, Edward D" sort="Huey, Edward D" uniqKey="Huey E" first="Edward D." last="Huey">Edward D. Huey</name><name sortKey="Huey, Edward D" sort="Huey, Edward D" uniqKey="Huey E" first="Edward D." last="Huey">Edward D. Huey</name><name sortKey="Huey, Edward D" sort="Huey, Edward D" uniqKey="Huey E" first="Edward D." last="Huey">Edward D. Huey</name><name sortKey="Huey, Edward D" sort="Huey, Edward D" uniqKey="Huey E" first="Edward D." last="Huey">Edward D. Huey</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Viner, Amanda S" sort="Viner, Amanda S" uniqKey="Viner A" first="Amanda S." last="Viner">Amanda S. Viner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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